DraftKings NFL 2021: Best lineup for Week 16

Cincinnati Bengals quarterback Joe Burrow (9) throws a pass as Denver Broncos defensive end Shelby Harris (96) pressures him in the first half of the NFL football game between the Bengals and the Broncos on Sunday, Dec. 19, 2021, at Empower Field in Denver.Cincinnati Bengals At Denver Broncos 373
Cincinnati Bengals quarterback Joe Burrow (9) throws a pass as Denver Broncos defensive end Shelby Harris (96) pressures him in the first half of the NFL football game between the Bengals and the Broncos on Sunday, Dec. 19, 2021, at Empower Field in Denver.Cincinnati Bengals At Denver Broncos 373 /
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Dec 20, 2021; Chicago, Illinois, USA; Minnesota Vikings wide receiver Justin Jefferson (18) looks on before the game against the Chicago Bears at Soldier Field. Mandatory Credit: Quinn Harris-USA TODAY Sports
Dec 20, 2021; Chicago, Illinois, USA; Minnesota Vikings wide receiver Justin Jefferson (18) looks on before the game against the Chicago Bears at Soldier Field. Mandatory Credit: Quinn Harris-USA TODAY Sports /

Wide Receiver 1: Justin Jefferson, Minnesota Vikings ($8,100)

Justin Jefferson has been an elite receiver, both in real life and in fantasy football. He’s the fifth receiver overall in PPR leagues, and he likely won’t slow down this week against the Rams in what has the potential to be a shootout.

Jefferson is another elite weapon that is deserving of our high-end spending. His matchup against the 23rd-ranked Rams’ secondary keeps him an elite option for us with overall WR1 upside this week.

Wide Receiver 2: Amon-Ra St. Brown, Detroit Lions ($5,600)

Amon-Ra St. Brown has become a target hog ever since the injury to T.J. Hockenson. In his last three games, he’s averaged 11.6 targets, 8.7 catches, and 83 yards. That is elite usage and production for the rookie wideout.

This week’s matchup with the 24th-ranked Atlanta secondary makes him a good bet to continue his hot streak, and he comes at a bargained price. He’s a solid WR2 for us this week.

Wide Receiver 3: Antonio Brown, Tampa Bay Buccaneers ($4,900)

Here we are, in Week 16, and the Bucs can’t wait to get Antonio Brown back from suspension after a reportedly faked vaccination card. The Bucs are welcoming him back with open arms, however, due to the injuries of Mike Evans and Chris Godwin.

Brown, due to his talent and wide open volume in Tampa Bay, will immediately become an elite fantasy option. This week’s matchup against Carolina isn’t great, but it ultimately won’t matter. Brown’s upside is too good to pass up, especially under $5,000.