1. Week 6: vs. Buffalo Bills (Sunday, Oct. 16)
This has the chance to be one of the best games on the schedule for the entire season. Everyone remembers the AFC Divisional round barnburner between the Chiefs and the Buffalo Bills. While Josh Allen’s defense let him down, he had no issues carving up the Kansas City defense on that January night. No doubt about it, he will want revenge, so Mahomes better be ready for this one.
While there is some debate over how good the Bengals will be the year after their breakthrough season, there is no question the Bills will be a Super Bowl 57 contender out of the AFC. One would argue they are the best team in football that has not got it done yet. Too bad the Chiefs have been their bugaboo over the last few years. All it takes is for Buffalo to win one of these games over K.C.
Simply put, the last thing the Chiefs will want to do is drop this one at home. Not only would the Bills have the head-to-head tiebreaker, but Buffalo will have a newfound confidence to beat them in the AFC playoffs. If you do not think this is a big deal, look at how Buffalo beat the New England Patriots last season after splitting their regular-season series in AFC East play. It propelled them.
Mahomes will have to match Allen seemingly throw for throw to be able to hold off the Bills here.