NFL Week 3 2022: Picks and predictions for every game

Aaron Rodgers, Green Bay Packers, Tom Brady, Tampa Bay Buccaneers. (Mandatory Credit: Kim Klement-USA TODAY Sports)
Aaron Rodgers, Green Bay Packers, Tom Brady, Tampa Bay Buccaneers. (Mandatory Credit: Kim Klement-USA TODAY Sports) /
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It’s already the final full week of the September slate for the 2022 NFL season, and we make our picks for who walks into October as winners.

As always, al lines are provided by our partners at WynnBet.

1-1. Thursday, Sept. 29. 1-1. 53. CLE -4.5. 55. AMAZON. 8:15 p.m. ET

Nothing says primetime football like Mitch Trubisky and Jacoby Brissett throwing for 5.5 yards per attempt in an all-you-can-eat check down fest.

Pick: Cleveland 17, Pittsburgh 14

CHI -3. 1 p.m. ET. 0-1-1. CBS. Sunday, Oct. 2. 1-1. 10. 57

If you’re watching this game, or you even plan to watch this game, seek help. Love yourself more. Consider better alternatives like spending a year with your in-laws or raking someone else’s lawn.

Pick: Chicago 19, Houston 17

0-2. FOX. Sunday, Oct. 2. 0-2. 35. LV -2. 28. 1 p.m. ET

Whoever loses is done, right? Not really. The Titans play in a horrid division, so they’d have hope. The Raiders, however, would be toast. They aren’t rebounding from 0-3 in the AFC West.

Pick: Las Vegas 31, Tennessee 27

2-0. 124. CBS. KC -6.5. 1 p.m. ET. Sunday, Oct. 2. 0-1-1. 46

One would expect the Colts, in their home opener, to come out with everything they have. The problem is they now employ defensive coordinator Gus Bradley, who last year with Las Vegas, saw his defense allow 89 points and seven touchdown passes to Patrick Mahomes and the Chiefs.

Pick: Kansas City 30, Indianapolis 20

2-0. CBS. 2-0. 59. BUF -5.5. 16. Sunday, Oct. 2. 1 p.m. ET

Best game of the week? Arguably. Two undefeated teams clash for the AFC East lead. Two questions face the Dolphins: can they block, and can they get a stop?

Pick: Buffalo 34, Miami 23

50. Sunday, Oct. 2. 1-1. 60. 1 p.m. ET. 1-1. FOX. MIN -6

This could go either way. If the Lions can create a few turnovers, they have a shot. The problem for them? This game isn’t in primetime, which means Kirk Cousins is about to look like Joe Montana.

Pick: Minnesota 28, Detroit 24

1-1. 26. FOX. BAL -3. Sunday, Oct. 2. 1-1. 47. 1 p.m. ET

The Ravens have to rebound after that miserable disaster of a fourth quarter on Sunday, and they should, because they’re more talented than New England in all three phases.

Pick: Baltimore 24, New England 20

1 p.m. ET. 0-2. 56. CBS. Sunday, Oct. 2. 30. 1-1. CIN -5

If the Bengals lose to the Jets, it’s over. Joe Burrow has been sacked 13 times in two games. Can New York get enough pressure to turn the tide in its favor?

Pick: Cincinnati 27, New York 17

54. Sunday, Oct. 2. 1-1. 58. PHI -6.5. 1 p.m. ET. 2-0. FOX

Philadelphia has a chance to run its record to 3-0, but needs to win on the road against an old friend and a divisional foe. This won’t be easy, but the Eagles are the better team with a much better defense.

Pick: Philadelphia 31, Washington 26

15. Sunday, Oct. 2. 87. 1-1. FOX. 0-2. NO -3. 1 p.m. ET

After watching Jameis Winston throw three interceptions amidst five New Orleans turnovers last week, Saints fans have to be hoping for a bounce-back showing. They should get one against Baker Mayfield and the Panthers, who haven’t shown much early.

Pick: New Orleans 24, Carolina 22