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DraftKings NFL 2022: Best lineup for Week 5

By Frankie Licausi

Sep 29, 2022; Cincinnati, Ohio, USA; Cincinnati Bengals quarterback Joe Burrow (9) looks to throw in the first quarter against the Miami Dolphins at Paycor Stadium in Cincinnati. Mandatory Credit: Kareem Elgazzar-USA TODAY Sports
Sep 29, 2022; Cincinnati, Ohio, USA; Cincinnati Bengals quarterback Joe Burrow (9) looks to throw in the first quarter against the Miami Dolphins at Paycor Stadium in Cincinnati. Mandatory Credit: Kareem Elgazzar-USA TODAY Sports /
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Oct 2, 2022; Atlanta, Georgia, USA; Cleveland Browns running back Nick Chubb (24) runs the ball against the Atlanta Falcons in the second half at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-USA TODAY Sports
Oct 2, 2022; Atlanta, Georgia, USA; Cleveland Browns running back Nick Chubb (24) runs the ball against the Atlanta Falcons in the second half at Mercedes-Benz Stadium. Mandatory Credit: Brett Davis-USA TODAY Sports /

RB1: Nick Chubb, Cleveland Browns ($8,000)

Nick Chubb has arguably been the best running back in the NFL this season. Second in the league in rushing yards with 459, he’s been the clear focal point of the Browns offense. He’s the current overall RB1 in fantasy points, beating out Saquon Barkley due to his five touchdowns.

Chubb’s dominance will continue this week against the Chargers’ third-worst run defense in terms of fantasy points allowed. Even Kareem Hunt will be a solid option in Week 5 with this dream matchup. Chubb will outperform our running backs this week and is on an incredible touchdown pace at 21.25. He’s a good bet to score another.

RB2: Damien Harris, New England Patriots ($5,600)

Damien Harris remains in a committee with Rhamondre Stevenson, who has out-snapped him by 29 snaps. However, Harris has outscored him in fantasy points by a solid margin. They seem to be in a near-even timeshare. However, with an incredible matchup this week, that won’t matter.

The New England Patriots take on the Detroit Lions, who have been a fantasy football point machine. They’ve allowed the second-most fantasy points to running backs on the year and just got torched by Rashaad Penny. In a game where the health of New England’s quarterbacks is uncertain, Harris is a solid play in this lineup.