NFL Week 5 2022: Picks and predictions for every game

CINCINNATI, OHIO - SEPTEMBER 29: Quarterback Joe Burrow #9 of the Cincinnati Bengals warms up prior to the game against the Miami Dolphins at Paycor Stadium on September 29, 2022 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images)
CINCINNATI, OHIO - SEPTEMBER 29: Quarterback Joe Burrow #9 of the Cincinnati Bengals warms up prior to the game against the Miami Dolphins at Paycor Stadium on September 29, 2022 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images)
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It’s time for the NFL Week 5 picks and predictions, and there are a litany of terrific games to break down for the weekend.

As always, all lines are provided by our partners at WynnBet.

Take both these teams — and their quarterbacks — to the glue factory. It’s going to be a battle of wills … for the teams and fans.

Pick: Denver 19, Indianapolis 17

The Giants are surprising early, while the Packers are underwhelming. Yet both are 3-1, largely because Green Bay is so much more talented than most. Expect the Packers to prevail.

Pick: Green Bay 27, New York 20

Tough to see the Buccaneers losing three straight games, let alone at home. Tom Brady will significantly outplay Marcus Mariota, and that’ll be the chief difference.

Pick: Tampa Bay 26, Atlanta 13

The Vikings have a propensity to make games like this interesting, but the Bears don’t have enough firepower to win.

Pick: Minnesota 28, Chicago 15

Points will be scored. The question is who is under center for the Patriots, and can the Lions get a few key stops?

Pick: New England 30, Detroit 28

The Jaguars are showing real progress. The Texans are not. Jacksonville should handle business at home against Houston.

Pick: Jacksonville 29, Houston 17

Toughest game to pick this week. Who the hell knows? Nick Chubb might run for 200 yards.

Pick: Cleveland 24, Los Angeles 23

How much of a difference is there between Teddy Bridgewater and Tua Tagovailoa? We’re about to  find out.

Pick: Miami 25, New York 23

This is going to be a ritualistic killing.

Pick: Buffalo 30, Pittsburgh 9

Why are the Saints favored by 5.5 points? They’ve been awful every game this season, while the Seahawks are 2-2 and playing really solid offense.

Pick: Seattle 24, New Orleans 22

Tennessee is back in business after winning the last two weeks, while Washington has lost three straight. Should be a close game, coming down to who makes a big mistake or two.

Pick: Tennessee 24, Washington 21