NFL Week 15 2022: Picks and predictions for every game

Buffalo Bills. (Photo by Joshua Bessex/Getty Images)
Buffalo Bills. (Photo by Joshua Bessex/Getty Images) /
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The NFL Week 15 picks are here, and the slate is one of the best we’ve seen yet in a season with plenty of twists still remaining.

9-4. 42. AMAZON. 36. SF -3.5. Thursday, Dec. 15. 7-6. 8:20 p.m. ET

The 49ers are playing their best ball of the season, while the Seahawks are scuffling. That said, Seattle is going to go full-out to beat San Francisco in a critical game.

Pick: San Francisco 27, Seattle 24

60. Saturday, Dec. 17. 10-3. 46. NFLN. MIN -4. 1 p.m. ET. 4-8-1

The Vikings only being favored by four points, at home, against the four-win Colts, tells you how little faith Vegas has in Minnesota. Perhaps rightfully so.

Pick: Minnesota 23, Indianapolis 17

Saturday, Dec. 17. CLE -3. 4:30 p.m. ET. 9-4. 26. NFLN. 5-8. 53

The Ravens are the better team, but they have no quarterback. Cleveland can win by playing a simple game.

Pick: Cleveland 20, Baltimore 14

59. Saturday, Dec. 17. 10-3. 8:15 p.m. ET. 8-5. NFLN. 16. BUF -7.5

The Bills are going to want revenge on Miami after losing to the Dolphins in Week 3. This is a huge game for Tua Tagovailoa and Co., but they are against a better team in bad weather.

Pick: Buffalo 28, Miami 23

FOX. Sunday, Dec. 18. 4-9. NO -4. 1 p.m. ET. 5-8. 15. 44

Desmond Ridder is making his first NFL start. However, while Saints head coach Dennis Allen is suited for a defensive coordinator role, he’s a good one. Expect him to make life hard on Ridder.

Pick: New Orleans 26, Atlanta 17

FOX. Sunday, Dec. 18. 52. DAL -4.5. 1 p.m. ET. 123. 10-3. 5-8

Jacksonville has become a fun conversation again, but the Cowboys still have faint hopes of the NFC East crown. After a scare against Houston, they’ll handle the Jags.

Pick: Dallas 29, Jacksonville 20

FOX. Sunday, Dec. 18. 30. 1 p.m. ET. 6-7. 7-6. PICK'EM. 50

Enormous game for both. The Lions are rolling and the Jets are beat up with quarterback Mike White taking tough hits in Buffalo. That said, Jared Goff has been a much different quarterback away from Ford Field.

Pick: New York 23, Detroit 21

Sunday, Dec. 18. 1-11-1. 1 p.m. ET. 124. CBS. 10. KC -14. 10-3

If the Chiefs make this interesting, it’s a five-alarm fire. The Texans are missing most of their stars, and are rotating Davis Mills and Jeff Driskel. This is also known as the No. 1 overall pick plan.

Pick: Kansas City 34, Houston 17

57. PHI -9. 54. 3-10. 1 p.m. ET. 12-1. FOX. Sunday, Dec. 18

Some see Chicago making this interesting as the Eagles aren’t playing for much and the Bears are off their bye. Put me down for a back-door cover.

Pick: Philadelphia 30, Chicago 24

1 p.m. ET. 55. Sunday, Dec. 18. 5-9. CAR -2.5. 5-9. CBS. 87

Both of these teams aren’t good, but the Panthers are somehow controlling their own destiny to host a playoff game.

Pick: Carolina 19, Pittsburgh 17