Barcelona and Sevilla have both struggled for form recently, raising the question of whether they peaked to early this season.
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Villarreal have been hugely underwhelming this season and find themselves four points adrift of safety ahead of a clash with Sevilla.
This weekend sees the latest clash between Quique Setien and Diego Simeone as Real Betis host Atletico Madrid in a battle of philosophies.
Signing Gonzalo Higuain on loan would be the ideal short-term fix for Chelsea as they aim to address their issues in front of goal.
Real Madrid will be desperate for revenge after being humiliated in a 3-0 loss at the Ramon Sanchez Pizjuan earlier in the season.
Athletic Bilbao and Sevilla come into this match on impressive unbeaten runs so both teams will be hoping to keep up the momentum.
Real Madrid travel to Real Betis in a match where both teams have the chance to make a statement after disappointing losses in the previous matchday.
La Liga has entered the Christmas break, so here's a look at the main stories from the season so far as Barcelona lead the league.
Sevilla travel to the capital to face Leganes in what could be a much tougher match than it looks based on the league table.
Barcelona finish the year against Miguel Cardoso's Celta Vigo and they will be hoping to maintain the three-point gap on Sevilla and Atletico Madrid.
The Champions League round of 16 draw is on Monday. Here's a look at the ideal draw, including a rematch of last season's final.
The latest edition of the Basque derby sees fifth place Alaves hosting an Athletic Bilbao side hoping for a resurgence under new manager Gaizka Garitano.
Real Betis will be hoping to enter the European places with a win over the Catalonian side while Espanyol will be hoping to end their winless run.
Sevilla have another opportunity to go top of the table if they can break down Marcelino's well-oiled Valencia machine this weekend.
The latest edition of the Catalan derby sees Barcelona aim to maintain their place at the top of the league table.
Alaves can leapfrog Sevilla with a win in a clash between the two surprises of the season. Here's what to expect from the Liga match.
Real Madrid's problems haven't yet been solved by Santiago Solari, but a win against Valencia this weekend will keep them in the title race.
Gareth Bale showed signs of promise as he opened the scoring in an important win for Real Madrid that secured first place in their Champions League group.
Another exciting weekend of La Liga action sees Barcelona face Atletico Madrid in a huge clash while Villarreal host Betis.
La Liga matchday 12 sees Espanyol and Sevilla clash in a battle of the contenders to challenge the usual top three and an assortment of other tasty matches.