San Francisco 49ers Odds

Latest San Francisco 49ers Betting Odds, Point Spread, Totals, Props, Parlay Picks, Predictions and Moneyline.

Seattle Seahawks quarterback Geno Smith.

Seahawks vs. 49ers Prediction, Odds, Spread and Over/Under for NFL Week 2 (Don't Write Geno Smith Off Again)

Jeff Wilson Jr. or Tyrion Davis-Price: Who Will Lead 49ers' Backfield Following Elijah Mitchell Injury?

Who Is George Kittle's Backup? (49ers’ Tight End Options After Kittle’s Groin Injury)

49ers vs. Bears Prediction, Odds, Spread and Over/Under for NFL Week 1 (Chicago Stays Surprisingly Close at Home)

Jimmy Garoppolo led the 49ers to two NFC Championship games and one Super Bowl in the last three seasons

Jimmy Garoppolo's Return to San Francisco Makes 49ers a Safe NFL Futures Bet

Trey Lance's dual-threat ability gives Kyle Shanahan a bevy of options as play-caller of the 49ers

49ers vs. Texans Prediction: Offensive Dynamism On Full Display in Preseason Week 3 Clash

August 12, 2022; Santa Clara, California, USA; San Francisco 49ers quarterback Trey Lance (5) throws

San Francisco 49ers 2022 NFL Season Betting Preview (Trey Lance Era Has Begun)

San Francisco 49ers quarterback Trey Lance (5)

49ers vs. Vikings Prediction: Trey Lance Needs the Reps

Trey Lance gets his first start as the starting quarterback for the 49ers in Week 1 of the preseason tonight

The Trey Lance Era Will Open With a Bang Against Green Bay

San Francisco 49ers wide receiver Brandon Aiyuk.

49ers Player Props: Buy Low on Brandon Aiyuk, Sell High on Deebo Samuel

Jimmy Garoppolo and Kyle Shanahan.

Kyle Shanahan Breaks His Silence on Jimmy Garoppolo's Future With 49ers

San Francisco 49ers quarterback Trey Lance.

3 NFL Teams to Avoid in Futures Market This Offseason

NFC Championship - San Francisco 49ers v Los Angeles Rams

3 Most Important Games on San Francisco 49ers' 2022 Schedule

Jacksonville Jaguars quarterback Trevor Lawrence

2022 NFL Dark Horse Division Winner Picks Post-NFL Draft (Don't be Scared of Extreme Turnarounds)

The NFL is returning to London and going to two more countries this year.

Here's Every NFL International Game for the 2022 Season

The Philadelphia Eagles were one of several teams to end up with a substantially improved roster following the 2022 NFL Draft.

2022 NFL Draft Grades for Every Team (Picks, Analysis, Super Bowl Odds)

Cleveland Browns quarterback Baker Mayfield waves to the fans at FirstEnergy Field in Cleveland.

Let's Set Odds: Where Will Baker Mayfield, Jimmy Garoppolo Be Traded Post-NFL Draft?

San Francisco 49ers quarterback Jimmy Garoppolo.

3 Players Most Likely to Be Traded During 2022 NFL Draft

49ers wide receiver Deebo Samuel appears to be on his way out of San Francisco after multiple reports state that he's not interested in an extension.

Let's Set Odds: Where Will the 49ers Trade Deebo Samuel?

Deebo Samuel has officially asked for a trade from the 49ers

49ers' Super Bowl Odds Would Plummet if They Trade Deebo Samuel

Trey Lance seems certain to be the starting quarterback of the 49ers in 2022 and beyond

Don't Buy in on Jimmy Garoppolo Starting Over Trey Lance for 49ers in 2022

Trey Lance could be the 49ers' starting quarterback in 2022.

49ers Writer Kicks Trey Lance Hype Into Overdrive