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NFL Week 6 2022: Picks and predictions for every game

By Matt Verderame

KANSAS CITY, MISSOURI - JANUARY 23: Running back Devin Singletary #26 of the Buffalo Bills carries the ball as cornerback L'Jarius Sneed #38 of the Kansas City Chiefs defends during the AFC Divisional Playoff game at Arrowhead Stadium on January 23, 2022 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images)
KANSAS CITY, MISSOURI - JANUARY 23: Running back Devin Singletary #26 of the Buffalo Bills carries the ball as cornerback L'Jarius Sneed #38 of the Kansas City Chiefs defends during the AFC Divisional Playoff game at Arrowhead Stadium on January 23, 2022 in Kansas City, Missouri. (Photo by Jamie Squire/Getty Images) /
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NEW ORLEANS, LOUISIANA – OCTOBER 09: Geno Smith #7 of the Seattle Seahawks reacts after a touchdown during the first half of the game against the New Orleans Saints at Caesars Superdome on October 09, 2022 in New Orleans, Louisiana. (Photo by Chris Graythen/Getty Images)
NEW ORLEANS, LOUISIANA – OCTOBER 09: Geno Smith #7 of the Seattle Seahawks reacts after a touchdown during the first half of the game against the New Orleans Saints at Caesars Superdome on October 09, 2022 in New Orleans, Louisiana. (Photo by Chris Graythen/Getty Images) /

FOX. Sunday, Oct. 16. 2-3. 4:05 p.m. ET. 2-3. 36. AZ -3. 32

This game could go either way, because Geno Smith is playing like a rockstar. That said, Arizona is the better team, and Kyler Murray should get going against the league’s worst defense.

Pick: Arizona 37, Seattle 32

4:05 p.m. ET. Sunday, Oct. 16. 2-3. 51. LAR -10.5. 1-4. 87. FOX

If the Rams can’t find a way to beat the Panthers with P.J. Walker under center and an interim head coach, they should fold the tent.

Pick: Los Angeles 30, Carolina 14

4-1. 124. 4:25 p.m. ET. 4-1. Sunday, Oct. 16. 16. CBS. BUF -3

Best game of the year. The Chiefs and Bills are the two top Super Bowl contenders, and they square off in a rematch of 13 Seconds.

I was ready to pick Buffalo, and then saw Vegas disrespected Patrick Mahomes and made him a home underdog. As a dog in his career, Mahomes is 6-2 straight up and never failed to cover the spread.

Pick: Kansas City 33, Buffalo 29

PHI -6. NBC. 123. Sunday, Oct. 16. 5-0. 54. 8:20 p.m. ET. 4-1

Another great game. The Eagles are the league’s lone unbeaten and can open up a two-game lead over Dallas in the NFC East with a victory. Look for the Eagles to ride the multi-faceted talents of Jalen Hurts to victory.

Pick: Philadelphia 22, Dallas 17

ESPN. Monday, Oct. 17. 3-2. LAC -5. 1 p.m. ET. 2-3. 45. 13

Good Lord, stop putting the Broncos in primetime. Nobody wants this.

Pick: Los Angeles 27, Denver 11

Last Week: 8-8
Season: 43-36-1

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