Ole Miss vs. Louisville prediction, odds, spread, line, over/under & betting info for NCAA Week 1

The Ole Miss Rebels will take on the Louisville Cardinals in Atlanta on Labor Day night.

It all comes down to this on Labor Day weekend, as the Ole Miss Rebels will face the Louisville Cardinals in Atlanta to cap off what should be an amazing Week 1 in college football.

This is Lane Kiffin’s second season in Oxford. While the Rebels have a high-octane offense, their defense need to be much improved if Ole Miss wants to crack the top 25 with an outside shot of getting back to Atlanta. As for Louisville, this is a prove-it year for Scott Satterfield. The Cardinals need to be pushing for bowl eligibility of they might have to look for a new head coach in 2022.

Here is what you need to know heading into Ole Miss’ season opener vs. Louisville on Monday.

Ole Miss vs Louisville Odds Week 1

According to WynnBET, Ole Miss is a 10.5-point favorite over Louisville in their neutral-site affair. The associated money lines for this game are the Rebels at -348 and the Cardinals at +275. The over/under for this game comes in at a combined 76 points.

Ole Miss Injury Report vs Louisville Week 1

Louisville looks to be at full strength, as safety Josh Minkins is expected to be back from the shoulder injury he has dealt with in January. He missed all of spring ball but should play some for the Cardinals. As for Ole Miss, none of their expected major contributors are dealing with significant injuries right now. So it looks to be full steam ahead for the Rebels when they head to Atlanta.

Ole Miss vs Louisville Prediction Week 1

We are going to know quite a bit about these two teams after Monday night’s game. There is a chance we could all be aboard the Lane Train once again if the Rebels light it up offensively. Should the Cardinals look rough, that could be a sign of more things to come for them this year. As long as Matt Corral does not turn the ball over, the Rebels should be able to win this one comfortably.

Prediction: Ole Miss 42, Louisville 28

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Ole Miss Next Game & Schedule

The Rebels’ next game will be back in Oxford, as they welcome the Austin Peay Governors to Vaught-Hemingway. Kickoff will be at 7:30 p.m. ET, 6:30 p.m. CT on Saturday, Sept. 11. The Cardinals will also be playing in primetime Week 2, as they will host the Eastern Kentucky Colonels. Kickoff for the Cardinals’ home opener will be at 7:00 p.m. ET on Saturday, Sept. 11.

What Channel is the Ole Miss Game On Week 1

ESPN will have the national telecast of this ACC vs. SEC showdown on Monday night. Kickoff is at 8:00 p.m. ET on Monday, Sept. 6 at Mercedes-Benz Stadium in Atlanta, Georgia.

Ole Miss vs Louisville Live Stream

If you are not able to attend the game in person or watch it on ESPN, you can always try fuboTV.

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