NFL Week 1 2021: Picks and predictions for every game

The Tampa Bay Buccaneers begin their title defense against the Dallas Cowboys, leading a great group of NFL Week 1 games.

All lines are from out partner, WynnBet.

Tough to see Dallas winning here. Young defense, Dak Prescott coming off injury, and the Buccaneers fully loaded after winning it all. Very tough spot for the Cowboys.

Pick: Tampa Bay 31, Dallas 23

We start the Sunday slate with two new head coaches. The Falcons are an explosive group offensively, but the defense is a mess. Philadelphia, though, doesn’t have the weaponry to fully take advantage. Expect a close game in Atlanta.

Pick: Atlanta 24, Philadelphia 20

Good game to kick things off. The Bills are the biggest challenger to Kansas City in the AFC, while Pittsburgh has been good for 30 years running. Buffalo should win, but the Steelers have a quality defense and enough weapons to keep things interesting.

Pick: Buffalo 22, Pittsburgh 19

If the Vikings don’t win this game, give it up. Minnesota has a ton of talent on both sides, and the Bengals are easing Joe Burrow back into the lineup following his torn ACL last year. Cincinnati will win some games this year, but this shouldn’t be one of them.

Pick: Minnesota 28, Cincinnati 23

No team has less talent than the Lions. Dan Campbell is going to be a good coach (I think), but the 49ers are a much better team trying to reestablish as a contender after an injury-marred 2020.

Pick: San Francisco 33, Detroit 12

Sneaky good game here. The Titans are going to throw for a million yards against Arizona’s secondary, but the same could be true in reverse. For sheer entertainment, the Titans and Cardinals might give us the best game of the weekend.

Pick: Tennessee 41, Arizona 36

What to make of the Colts? Tons of injuries this summer, COVID problems, and Carson Wentz. In fact, Wentz really checks all the aforementioned boxes. The Seahawks have the much better quarterback and weapons, so they win a tight one on the road.

Pick: Seattle 24, Indianapolis 21

Two really intriguing teams. The Chargers have playoff talent, especially after fortifying the offensive line in front of Justin Herbert. That group will be tested immediately, as Washington might have the best front seven in football. If Ryan Fitzpatrick is good, look out.

Pick: Washington 23, Los Angeles 19

The Jets are starting a new era with Robert Saleh on the sideline and Zach Wilson under center. While that tandem may prove terrific, the Panthers have more talent and are at home.

Pick: Carolina 26, New York 23

Call the police.

Pick: Jacksonville 24, Houston 18