Ohio State vs. Oregon prediction, odds, spread, line, over/under & betting info for NCAA Week 2

Ohio State welcomes Oregon to Columbus in Week 2 of college football and we have predictions, odds and everything you need for the game. 

Despite entering the 2021 college football season as the favorites in their respective conferences, both the Ohio State Buckeyes and Oregon Ducks got scares to open up their years. Ryan Day’s team got all they could handle against Minnesota while Mario Cristobal’s program needed a late touchdown to get past Fresno State. Now, they’re set to try and right the ship when they face one another in Week 2.

While we often see these high-profile cross-conference matchups take place at neutral sites, this game will be played at Ohio Stadium with a raucous Buckeyes crowd affecting the action as best they can. That’s probably why Ohio State comes into this game as a heavy favorite over Oregon, or at least part of the reason.

This is easily the biggest game in Week 2 of the college football season. So we’re breaking down every aspect to help prepare you for it and guide you on how to bet on the action.

Ohio State vs. Oregon Odds NCAA Week 2

Point Spread: Ohio State -14.5
Moneyline: Ohio State -640, Oregon +460
Over/Under: 63.5 points
Odds via WynnBet

The Buckeyes are more than two touchdown favorites in this game, which is a bit shocking. With a young quarterback that took a couple of quarters to get rolling last week now facing a better defense in addition to the OSU defense having problems of its own, taking them as that heavy of a favorite would be a bit unwise. The over, however, is quite appealing.

Ohio State injury report vs. Oregon NCAA Week 2

The Ohio State secondary, a unit that had concerns about depth and starters coming into the year, is a bit worrisome from a health perspective. Sevyn Banks, Cameron Brown and Josh Proctor are all banged up and head coach Ryan Day has not provided a meaningful update on their status against Oregon. Their health is something critical to watch for this game.

Kayvon Thibodeaux Injury Update

Oregon star pass-rusher Kayvon Thibodeaux suffered a sprained ankle in the win over Fresno State and left the stadium in a walking boot. He’s being called day-to-day and the Ducks coaching staff has yet to commit to whether or not the potential top-five pick in the 2022 NFL Draft will play on Saturday in this matchup.

Ohio State vs. Oregon Prediction NCAA Week 2

Because the Buckeyes were able to turn it on at the end of the game against Minnesota, it feels as if their shortcomings are being overlooked. But the Gophers pushed this team with a worse defense and worse offensive weapons than what Oregon can throw at them for this game. Throw in a banged-up secondary and that starts to look secondary.

Ohio State has more talent than the Ducks but their holes are more glaring as well. Despite the fact that Oregon is the big underdog in this matchup, I like them to pull off the upset and claim a signature win for the Pac-12. Final Score: Oregon 36, Ohio State 30

Make your pick now on WynnBET.

Ohio State Next Game and Schedule

• Sept. 18: vs. Tulsa
• Sept. 25: vs. Akron
• Oct. 2: at Rutgers
• Oct. 9: vs. Maryland
• Oct. 23: at Indiana
• Oct. 30: vs. Penn State
• Nov. 6: at Nebraska
• Nov. 13: vs. Purdue
• Nov. 20: vs. Michigan State
• Nov. 27: at Michigan

After this matchup against the Ducks, the Buckeyes get to breathe a bit as they face some pretty easy opponents. Based on the early returns this season, it feels safe to say that they can turn on cruise control and iron out the kinks until the end of October when Penn State comes to Columbus.

What Channel is the Ohio State vs. Oregon Game on NCAA Week 2?

You can catch the Ohio State vs. Oregon matchup featuring two top-15 teams on FOX as part of the Big Noon Saturday game of Week 2.

Ohio State vs. Oregon Live Stream

Date: Saturday, Sept. 11
Kickoff Time: Noon ET
TV Channel: FOX
Live Stream: FuboTV (7-day free trial available)

Fans can tune into the Week 2 game between Ohio State and Oregon on FOX, which means you can live stream the contest on FuboTV, which is available for a 7-day free trial for new users signing up for a subscription. You can also watch on FOX Sports and the FOX Sports app by logging in with a valid cable or satellite subscription.

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