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Iowa vs. Iowa State prediction, odds, spread, line, over/under & betting info for NCAA Week 2

By Cody Williams

Sep 4, 2021; Iowa City, Iowa, USA; Iowa Hawkeyes running back Tyler Goodson (15) reacts after a 67 yard touchdown run against the Indiana Hoosiers during the first quarter at Kinnick Stadium. Mandatory Credit: Jeffrey Becker-USA TODAY Sports
Sep 4, 2021; Iowa City, Iowa, USA; Iowa Hawkeyes running back Tyler Goodson (15) reacts after a 67 yard touchdown run against the Indiana Hoosiers during the first quarter at Kinnick Stadium. Mandatory Credit: Jeffrey Becker-USA TODAY Sports /
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Iowa and Iowa State renew the always-heated CyHawk rivalry on Saturday at Jack Trice Stadium and we have everything college football fans need for the game.

Ahead of another epic battle for the CyHawk Trophy, the Iowa Hawkeyes and Iowa State Cyclones had very different starts to the 2021 college football season. In the case of the former, they played a ranked Indiana team and dominated them, leaving no doubt. The latter, however, played FCS Northern Iowa and needed all 60 minutes to pull out a narrow victory ahead of the rivalry game in Week 2.

This is supposed to be the golden age of Cyclones football and they very much could’ve been looking ahead. But at the same time, head coach Matt Campbell has never gotten a victory over his in-state rivals since he arrived in Ames, despite all the success he’s had. Kirk Ferentz and the Hawkeyes certainly have no intentions of changing that trend either.

So how will one of the biggest games of college football Week 2 play out? We have the game covered from every angle to help you prepare.

Iowa vs. Iowa State Odds NCAA Week 2

Point Spread: Iowa State -4.5
Moneyline: Iowa State -195, Iowa +165
Over/Under: 46.5 points
Odds via WynnBet

If nothing else, you can’t say the oddsmakers are overreacting to what happened in Week 1. The Hawkeyes were the clearly more dominant team out of the two competing for the CyHawk Trophy, yet the Cyclones getting to play at Ames is apparently enticing enough to instill them as over four-point favorites.

My gut tells me to lean towards the Hawkeyes in this one as they’ve dominated the rivalry and should certainly keep this one close even if they don’t get the win. Moreover, the under has been cashing tremendously well in this rivalry, so my lean stays there as well.

Iowa injury report vs. Iowa State NCAA Week 2

The Hawkeyes are expected to be without starting guard Kyler Schott for the second straight week after he injured himself on the family farm. Moreover, it’ll be interesting to watch the health of wide receiver Charlie Jones after he left the season-opener with an injury.

Charlie Kolar Injury Update

In the scare against an FCS opponent to open the year, the Cyclones were without All-American tight end Charlie Kolar due to an ankle injury. That certainly had a big effect on the haphazard offense but things do seem a bit optimistic. The Iowa State coaching staff indicated that they are confident in the tight end’s recovery, indicating that he and their other key injuries should be able to play against their in-state rivals.

Iowa vs. Iowa State Prediction NCAA Week 2

All told, we’re not going to read too much into what we saw last week. NIU is a tough team and there’s a good chance the Cyclones just weren’t tipping their hand for this game. On top of that, the Hawkeyes did get some fortunate turnover luck to win so emphatically over Indiana in their season-opener.

While that all might be true, Iowa just looked like the better football team in Week 1 and I can’t shake that as they come into this matchup as an underdog and not having lost to their rivals since Matt Campbell took over the Cyclones. That’s going to play into this one and the fans in Ames are, ultimately, going to be let down once again. Final Score: Iowa 20, Iowa State 18

Make your pick now on WynnBET.

Iowa Next Game and Schedule

  • Sept. 18: vs. Kent State
  • Sept. 25: vs. Colorado State
  • Oct. 1: at Maryland
  • Oct. 9: vs. Penn State
  • Oct. 16: vs. Purdue
  • Oct. 30: at Wisconsin
  • Nov. 6: at Northwestern
  • Nov. 13: vs. Minnesota
  • Nov. 20: vs. Illinois
  • Nov. 26: at Nebraska

Once the Hawkeyes get past this game, the sledding is quite easy for Ferentz and his team before they get into Big Ten play in October. Both Kent State next week and Colorado State the week after are tough matchups that could potentially trip them up.

What Channel is the Iowa vs. Iowa State Game on NCAA Week 2?

Fans can catch this high-profile matchup between two bitter in-state rivals on ABC this Saturday, meaning it should be available on any cable or satellite provider or through using an antenna to pick up the local ABC affiliate.

Iowa vs. Iowa State Live Stream

Date: Saturday, Sept. 11
Kickoff Time: 4:30 p.m. ET
TV Channel: ABC
Live Stream: FuboTV (7-day free trial available), WatchESPN

Fans can tune into the Week 2 game between Ohio State and Oregon on ABC, which means you can live stream the contest on FuboTV, which is available for a 7-day free trial for new users signing up for a subscription. You can also watch on WatchESPN or any ABC apps on your devices when you log in with a valid cable or satellite subscription.

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