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College football upset picks Week 11: Ohio State and 5 teams on upset alert

By Nick Villano

Helmets of the Ohio State Buckeyes on the sidelines during the game against the Nebraska Cornhuskers in the second half at Memorial Stadium on November 6, 2021 in Lincoln, Nebraska. (Photo by Steven Branscombe/Getty Images)
Helmets of the Ohio State Buckeyes on the sidelines during the game against the Nebraska Cornhuskers in the second half at Memorial Stadium on November 6, 2021 in Lincoln, Nebraska. (Photo by Steven Branscombe/Getty Images) /
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Pittsburgh Panthers
Kenny Pickett #8 of the Pittsburgh Panthers. (Photo by Justin Berl/Getty Images) /

College football upset picks for Week 11 as Ohio State and several other ranked teams could be in trouble and are on upset alert this week.

What a wild weekend in college football. One team lost in a huge way, as Michigan State went from title contender to out of the playoff due to their loss to Purdue. The Boilermakers have been an upset machine before, taking out the number two team in the country in Iowa earlier this season.

That wasn’t the only major upset in Week 10. Wake Forest lost its top ten status and undefeated season despite scoring 55 points against the North Carolina Tar Heels. Then No.12 Baylor lost to a TCU team that just fired Gary Patterson after 20 years on the sidelines. Minnesota lost at home to Illinois. Fresno State got their teeth kicked in by Boise State. There were a lot of fun games, as long as you weren’t betting on the other side.

This week, there are some juicy upset picks. Which plays should bettors be keeping an eye on?

Note: All odds are courtesy of WynnBET. For more betting info and content, visit BetSided.

College football upset pick Week 11, No. 5: Pittsburgh

Rank: 25 | Opponent: vs. North Carolina | Time: Thursday, Nov. 11, 7:30 p.m. ET

The Pitt Panthers have been on this list often mostly because of how strange the ACC is this season. The Panthers are getting six points according to WynnBett despite the Tar Heels coming off a win against the top team in the conference. They scored 58 points against Wake Forest, and they are coming into Pittsburgh smelling blood.

It’s been a mess this season for North Carolina, but they are still one win away from being bowl eligible. Sam Howell could salvage his NFL Draft stock with a few more good performances in a class of quarterbacks that’s weak, to say the least. There’s a lot still motivating the Tar Heels to destroy other teams, and the Panthers are now in their way.

Pitt has to play at home on a Thursday with a few players out of the lineup or playing hurt. It’s really impacting the offensive and defensive lines. North Carolina will be able to take advantage of this and pull out a nail-biter.

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