College football upset picks Week 12: Oklahoma and 5 teams on upset alert

College football upset picks for Week 12 as Oklahoma and several other ranked teams could be in trouble and are on upset alert this week.

The College Football Playoff committee would not relent on keeping Oklahoma outside of the College Football Playoff top four despite the team leading the Big 12 and going undefeated to start the season. Finally, the committee was proven right as Oklahoma lost to Baylor on the road over the weekend. It basically puts a stake into any hopes the Sooners had to play for a championship this season.

That wasn’t the only upset last week. Auburn was the other big upset as they lost to Mississippi State on the road. However, the upset watch focused mainly on Florida, which was trying to avoid one of the biggest upsets in program history against Sanford. Not only is Sanford an FCS team, but they are an FCS team with a losing record. Despite this, they once had a 42-28 lead over the Gators. It would have been one of the biggest upsets of the year, but the Gators were able to score 70 points to outpace their opponents.

This week, there are some incredible matchups across the board. Ohio State and Michigan State face off. Oregon faces its toughest test since they beat the Buckeyes in Columbus. It will be a big week for coverage, but let’s focus on the upsets. Here’s where bettors should take a hard look at the matchup because there could be a good matchup to take advantage of.

Note: All odds are courtesy of WynnBET. For more betting info and content, visit BetSided.

College football upset pick Week 12, No. 5: Oklahoma

Rank: 13 | Opponent: vs. Iowa State | Time: Saturday, Nov. 20, Noon ET

Oklahoma finally watched the pipe burst after patching it with Scotch Tape for the past six weeks. Too many close losses, too many bad headlines, and too many mistakes finally led to a loss this past weekend as Baylor takes over as the top team in the Big 12.

This week, Oklahoma takes on Iowa State, which has been cagey with the Sooners as of late. The Cyclones have eight wins in the history of this rivalry. Two of those eight wins have come in the past five years, where this rivalry has taken it up a notch. That includes a huge win in Norman five years ago.

Iowa State is having one of the most disappointing seasons in the country, and it got worse last week with a loss to Texas Tech. This is their entire season. This one game means more to Iowa State than any game this week means to anyone else. There is a lot of talent on this Iowa State team, and it will come to play this week on the road. Oklahoma is getting 4.5 points here, and it will be an upset straight up.