NFL Week 16 2021: Picks and predictions for each game

ORCHARD PARK, NEW YORK - DECEMBER 19: Gabriel Davis #13 of the Buffalo Bills carries the ball for fourteen-yard touchdown in the fourth quarter over the Carolina Panthers the game at Highmark Stadium on December 19, 2021 in Orchard Park, New York. (Photo by Kevin Hoffman/Getty Images)
ORCHARD PARK, NEW YORK - DECEMBER 19: Gabriel Davis #13 of the Buffalo Bills carries the ball for fourteen-yard touchdown in the fourth quarter over the Carolina Panthers the game at Highmark Stadium on December 19, 2021 in Orchard Park, New York. (Photo by Kevin Hoffman/Getty Images) /
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It’s time four our NFL Week 16 picks, and there are a litany of excellent games on the docket to break down with playoff implications.

As always, our lines are brought to you by our great partners at WynnBet.

35. NFLN. Thursday, Dec. 23. SF -3.5. 8:20 p.m. ET. 8-6. 42. 9-5

It’s odd to see a home team, with a better record, on a short week, getting points. And yet it feels correct. The Niners are far healthier and much hotter. Take the Niners in a tight one.

Pick: San Francisco 24, Tennessee 19

49. GB -8. 4:30 p.m. ET. NFLN. Saturday, Dec. 25. 11-3. 7-7. 53

Tough to see the Browns going into Green Bay on a short week and beating the Packers. Hell, it’s tough to see it with Cleveland having a month to prepare.

Pick: Green Bay 31, Cleveland 23

32. AZ -1. 8:15 p.m. ET. 46. 10-4. Saturday, Dec. 25. 8-6. NFLN

If the Cardinals lose this game, they’re in full-blown freefall. That said, Arizona is the more talented team with the superior quarterback. It bounces back here.

Pick: Arizona 26, Indianapolis 23

13. 10. 1 p.m. ET. 8-6. CBS. Sunday, Dec. 26. 3-11. LAC -9.5

The Chargers have to be sick after last Thursday night, and they’ll take their frustrations out on the Texans in Houston.

Pick: Los Angeles 33, Houston 20

26. CBS. Sunday, Dec. 26. 8-6. CIN -2.5. 1 p.m. ET. 8-6. 56

Huge, huge AFC North battle. The Bengals won 41-17 in their first matchup with the Ravens. This will be much closer, but how does Baltimore slow down Cincinnati’s passing attack?

Pick: Cincinnati 34, Baltimore 30

9-5. 8-6. Sunday, Dec. 26. 47. NE -2.5. 1 p.m. ET. 16. CBS

This is the AFC East championship. If the Bills win, they merely need to beat the Falcons and Jets at home to win the division. If New England wins, any other win or Dolphins loss clinches it.

Pick: Buffalo 27, New England 23

6-8. 44. 1 p.m. ET. 2-11-1. 50. FOX. Sunday, Dec. 26. ATL -4

The Falcons probably win, but would anybody be surprised if the Lions went in and won by 20?

Pick: Atlanta 29, Detroit 19

2-12. CBS. Sunday, Dec. 26. 3-11. 52. 30. NYJ -2. 1 p.m. ET

God almighty.

Pick: New York 22, Jacksonville 18

10-4. 51. Sunday, Dec. 26. 7-7. 60. LAR -2.5. 1 p.m. ET. FOX

The Rams have a real shot at a top-three seed in the NFC, and while the Vikings will also be fighting hard, Los Angeles is the better team.

Pick: Los Angeles 32, Minnesota 28

4-10. Sunday, Dec. 26. 7-7. PHI -10. 31. FOX. 54. 1 p.m. ET

If the Giants win another game this season, the losing team should be forced to play in the MAC next year. New York is beyond cooked.

Pick: Philadelphia 28, New York 17

48. FOX. Sunday, Dec. 26. 5-9. 87. TB -11.5. 10-4. 1 p.m. ET

The Buccaneers are going to be short-handed and it’s a division game, but Carolina is ready for the offseason and Tom Brady won’t let Tampa Bay lose two straight.

Pick: Tampa Bay 26, Carolina 13