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NFL Week 2 2022: Picks and predictions for every game

By Matt Verderame

SEATTLE, WASHINGTON - OCTOBER 25: Jameis Winston #2 of the New Orleans Saints looks on against the Seattle Seahawks during the fourth quarter at Lumen Field on October 25, 2021 in Seattle, Washington. (Photo by Steph Chambers/Getty Images)
SEATTLE, WASHINGTON - OCTOBER 25: Jameis Winston #2 of the New Orleans Saints looks on against the Seattle Seahawks during the fourth quarter at Lumen Field on October 25, 2021 in Seattle, Washington. (Photo by Steph Chambers/Getty Images) /
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After a fascinating Week 1, we move ahead to Week 2 of the NFL season and check out the best games while picking them all.

Last week, we fell just below the .500 mark. Typical Week 1. We rebound, right now. As always, all line provided by WynnBet.

1-0. 13. 1-0. 124. AMAZON. Thursday, Sept. 15. KC -4. 8:15 p.m. ET

Best game of the year. The Chiefs and Chargers will battle for the AFC West all year. If Kansas City wins, it’s an early lead and a great win. If Los Angeles wins, the Chargers take their toughest road game of the year.

Pick: Kansas City 27, Los Angeles 24

Sunday, Sept. 18. CLE -6. 1 p.m. ET. 0-1. 30. CBS. 1-0. 53

Jacoby Brissett and Joe Flacco. After you call the police on this game, sit down and expect a defensive struggle with a ton of running. That favors the team with Nick Chubb and Kareem Hunt.

Pick: Cleveland 20, New York 17

58. Sunday, Sept. 18. 50. DET -2.5. 1-0. FOX. 0-1. 1 p.m. ET

If Washington wins, perhaps the Commanders are more of a threat in the NFC East than previously believed. However, the Lions are playing to keep hope going after a tough Week 1 loss.

Pick: Detroit 24, Washington 22

FOX. Sunday, Sept. 18. 1-0. 15. 1 p.m. ET. 1-0. 48. TB -3

Excellent divisional clash, and the Bucs are trying to win their first regular-season game over the Saints in the Tom Brady era. The big issue for Tampa Bay? Injuries galore.

Pick: New Orleans 27, Tampa Bay 24

1-0. NYG -2.5. 1 p.m. ET. 0-1. 87. FOX. Sunday, Sept. 18. 31

Love the fight we saw from the Giants in Nashville, earning a last-second win. Carolina is more talented, but New York looks unified under first-year head coach Brian Daboll.

Pick: New York 22, Carolina 18

0-1. 47. Sunday, Sept. 18. CBS. 1-0. 55. NE -1.5. 1 p.m. ET

Offensive football is about to be set back to 1938. Pittsburgh and New England are both hoping to play defense, win situational battles, get a few turnovers and capitalize when they come.

Pick: Pittsburgh 17, New England 16

0-0-1. 46. CBS. Sunday, Sept. 18. 0-1. 52. IND -4. 1 p.m. ET

The Colts have to win this game. They can’t come out of tilts against the Texans and Jaguars without a victory. Meanwhile, if Jacksonville goes 0-2, it feels like more of the same for this downtrodden franchise.

Pick: Indianapolis 25, Jacksonville 23

BAL -3.5. 1 p.m. ET. 59. CBS. Sunday, Sept. 18. 1-0. 26. 1-0

The Ravens and Dolphins both looked good in Week 1. Baltimore is the more complete team, at home. Tua Tagovailoa will need to have a great game to crack the Ravens’ defense.

Pick: Baltimore 31, Miami 19

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