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NFL Week 5 2022: Picks and predictions for every game

By Matt Verderame

CINCINNATI, OHIO - SEPTEMBER 29: Quarterback Joe Burrow #9 of the Cincinnati Bengals warms up prior to the game against the Miami Dolphins at Paycor Stadium on September 29, 2022 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images)
CINCINNATI, OHIO - SEPTEMBER 29: Quarterback Joe Burrow #9 of the Cincinnati Bengals warms up prior to the game against the Miami Dolphins at Paycor Stadium on September 29, 2022 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images) /
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It’s time for the NFL Week 5 picks and predictions, and there are a litany of terrific games to break down for the weekend.

As always, all lines are provided by our partners at WynnBet.

AMAZON. 45. DEN -3.5. 8:20 p.m. ET. 1-2-1. 46. Thursday, Oct. 6. 2-2

Take both these teams — and their quarterbacks — to the glue factory. It’s going to be a battle of wills … for the teams and fans.

Pick: Denver 19, Indianapolis 17

49. NFLN. 3-1. 9:30 p.m. ET. 3-1. Sunday, Oct. 9. 31. GB -8

The Giants are surprising early, while the Packers are underwhelming. Yet both are 3-1, largely because Green Bay is so much more talented than most. Expect the Packers to prevail.

Pick: Green Bay 27, New York 20

2-2. TB -8.5. 48. 1 p.m. ET. 44. FOX. Sunday, Oct. 9. 2-2

Tough to see the Buccaneers losing three straight games, let alone at home. Tom Brady will significantly outplay Marcus Mariota, and that’ll be the chief difference.

Pick: Tampa Bay 26, Atlanta 13

Sunday, Oct. 9. 2-2. 57. FOX. 3-1. 60. MIN -7. 1 p.m. ET

The Vikings have a propensity to make games like this interesting, but the Bears don’t have enough firepower to win.

Pick: Minnesota 28, Chicago 15

FOX. 47. NE -3. 1 p.m. ET. 1-3. 50. Sunday, Oct. 9. 1-3

Points will be scored. The question is who is under center for the Patriots, and can the Lions get a few key stops?

Pick: New England 30, Detroit 28

10. Sunday, Oct. 9. 52. JAX -7. 1 p.m. ET. 0-3-1. CBS. 2-2

The Jaguars are showing real progress. The Texans are not. Jacksonville should handle business at home against Houston.

Pick: Jacksonville 29, Houston 17

Sunday, Oct. 9. LAC -2.5. 1 p.m. ET. CBS. 13. 2-2. 53. 2-2

Toughest game to pick this week. Who the hell knows? Nick Chubb might run for 200 yards.

Pick: Cleveland 24, Los Angeles 23

CBS. Sunday, Oct. 9. MIA -3. 3-1. 59. 2-2. 30. 1 p.m. ET

How much of a difference is there between Teddy Bridgewater and Tua Tagovailoa? We’re about to  find out.

Pick: Miami 25, New York 23

3-1. CBS. Sunday, Oct. 9. 16. BUF -14. 1 p.m. ET. 1-3. 55

This is going to be a ritualistic killing.

Pick: Buffalo 30, Pittsburgh 9

2-2. 36. 1-3. 15. NO -5.5. FOX. Sunday, Oct. 9. 1 p.m. ET

Why are the Saints favored by 5.5 points? They’ve been awful every game this season, while the Seahawks are 2-2 and playing really solid offense.

Pick: Seattle 24, New Orleans 22

1 p.m. ET. 2-2. CBS. Sunday, Oct. 9. TEN -2.5. 35. 1-3. 58

Tennessee is back in business after winning the last two weeks, while Washington has lost three straight. Should be a close game, coming down to who makes a big mistake or two.

Pick: Tennessee 24, Washington 21

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