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NFL Week 5 2022: Picks and predictions for every game

By Matt Verderame

CINCINNATI, OHIO - SEPTEMBER 29: Quarterback Joe Burrow #9 of the Cincinnati Bengals warms up prior to the game against the Miami Dolphins at Paycor Stadium on September 29, 2022 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images)
CINCINNATI, OHIO - SEPTEMBER 29: Quarterback Joe Burrow #9 of the Cincinnati Bengals warms up prior to the game against the Miami Dolphins at Paycor Stadium on September 29, 2022 in Cincinnati, Ohio. (Photo by Dylan Buell/Getty Images) /
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Oct 3, 2022; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) is tackled by Los Angeles Rams linebacker Ernest Jones (53) during the third quarter at Levi’s Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports
Oct 3, 2022; Santa Clara, California, USA; San Francisco 49ers wide receiver Deebo Samuel (19) is tackled by Los Angeles Rams linebacker Ernest Jones (53) during the third quarter at Levi’s Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports /

42. CBS. 87. SF -6.5. 4:05 p.m. ET. 2-2. Sunday, Oct. 9. 1-3

Baker Mayfield against the Niners defense. That should be put behind a pay-per-view surcharge.

Pick: San Francisco 20, Carolina 9

3-1. 123. Sunday, Oct. 9. 51. LAR -5.5. FOX. 2-2. 4:25 p.m. ET

Can the Rams block the Cowboys? Feels like Matthew Stafford could be looking up at the SoFi Stadium roof a ton. That said, can Dallas score enough?

Pick: Los Angeles 22, Dallas 20

Sunday, Oct. 9. 32. 4:25 p.m. ET. 4-0. 54. FOX. PHI -5. 2-2

At some point, the Eagles are going to lose. Is this a trap game with the Cowboys next? Maybe, but tough to pick Arizona against a decent team.

Pick: Philadelphia 24, Arizona 21

NBC. Sunday, Oct. 9. 2-2. 26. 8:20 p.m. ET. 2-2. 56. BAL -3

Best game of the week. Whoever loses will be 2-3, while the winner has a lead in the AFC North and a critical win. I’ll take the better passing game, and better defense.

Pick: Cincinnati 34, Baltimore 30

1-3. Monday, Oct. 10. 124. KC -7. 8:15 p.m. ET. 28. ESPN. 3-1

What’s the case for Las Vegas stopping Kansas City’s offense? Just too many weapons against a defense with Maxx Crosby and little else.

Pick: Kansas City 35, Las Vegas 23

Last Week: 10-6
Season: 35-28-1

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