
The Midwest bracket is perhaps one of the toughest brackets in the tournament, and not in the sense that the West is tough. The West bracket is tough from a standpoint that itās tough to predict, while the Midwest is tough to endure as itās loaded with both solid teams in high seeds and upsets threats in lower seeds.

Louisvilleās road to the Final Four isnāt impossible but itās not going to be the easiest road either. The Cardinals snagged the top overall seed but it might not be because theyāre the best team but rather the only respectable team getting a No. 1 seed. But the Cardinals are flying high right now and theyāre one of the hottest teams in college basketball at the moment, which is really the only requirement you need in order to make a deep run. Theyāve got experience, theyāve got talent and theyāre hot which equates to a dangerous team that wonāt cool off until at least the Elite Eight.
[RELATED:Ā West Region Preview]

For some reason the Oregon Ducks were given a bubble seed and drew the No. 12 slot in the Midwest. But already analysts are predicting that Oregon will be dangerous to deal with and theyāre poised to make a deep run in their bracket. Their first opponent is Oklahoma State, who arenāt a bad team but also arenāt heavily favored to win. Oregon out hustles and outlasts their opponents and thatās bad news for the sluggish Cowboys and the New Mexico State and the offensively challenged Saint Louis Billikens. They wonāt make it to the Final Four, but the Ducks are going to spoil a lot of fun fir higher seeds up until theyāre ultimately beaten by Louisville.
But speaking of Saint Louis, the Billikens are looking at playing the Ducks in the third round, and it could end up being one of the better games of the tournament. Saint Louis is a motivated team, as the death of head coaching legend Rick Majerus is the fire fueling them on this run theyāre on. As a No. 4 seed itās tough to call them a cinderella, but if they can play lock down defense, an upset over Louisville is not out of the question for this emotionally motivated squad.
[RELATED: South Region Preview]

Itās tough to call a No. 10 seed a weak seed, as itās not a particularly high ranking. But the Cincinnati Bear Cats will undoubtedly run into trouble immediately if they manage an upset over Creighton in the second round. They canāt shoot and they force themselves to make up for it by grabbing offensive boards. The same can be said for Oklahoma State, who have struggled all season with consistency beyond the arc. The NCAA doesnāt always seed teams as well as they should and Oklahoma Stateās No. 5 seed is an example of that, but Memphis drawing the sixth seed in the region deserves an even bigger raise of the eyebrow. The Tigers arenāt that great from the stripe and defensively theyāre not the best team either, and you have to look no further than Southern Mississippi almost upsetting them in the Conference USA title game for proof.
All three teams possess the potential to win their Round of 64 matchups, but they more than likely will be tested to their limits en route to said victory. When it comes to the likes of Oklahoma State and Cincinnati in particular, you may be better off getting them off your bracket in the first round as both are candidates to be beaten, while Memphis isnāt poised to last much further than the Round of 32.
[RELATED: East Region Preview]

Without a doubt the two strongest seeds in the region are Rick Pitinoās Louisville Cardinals and Tom Izzoās Michigan State Spartans. Like we said, the Cardinals are red hot at the moment and seem to be virtually unstoppable, while the Spartanās make up for a so-so resume by boasting some impressive swagger of their own. Duke is a threat to wind up in the Elite Eight, and they actually could cause some problems for the Cardinals as they beat Louisville by 5 earlier this season. But the Blue Devils are too unstable to be a reliable pick for the Elite Eight and could get bogged down by the Spartans stout defense in the Sweet Sixteen.
As for Louisville, their toughest test would be taking on Oregon, as the Ducks beat teams based on sheer grit and may end up stifling the Cardinals long enough to pull off a miracle. But if all goes as it should, the Cardinals will roll to an Elite Eight appearance and eventually a trip to the Final Four.

Louisville is the team to beat in the Midwest region, and may arguably be the team to beat in the entire tournament.Ā Theyāve held their opponents to below 60 points 21 times this season, which means their defense is more than capable of leading the charge in big games. Theyāre hot, theyāre talented and theyāre dangerous which is the makings of a March Madness team built for success.
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