March Madness 2022: 10 best potential games we’re looking forward to watching

Tennessee guard Kennedy Chandler (1) defends Arizona guard Kerr Kriisa (25) during a basketball game between the Tennessee Volunteers and the Arizona Wildcats at Thompson-Boling Arena in Knoxville, Tenn., on Wednesday, Dec. 22, 2021.Kns Vols Arizona Hoops Bp
Tennessee guard Kennedy Chandler (1) defends Arizona guard Kerr Kriisa (25) during a basketball game between the Tennessee Volunteers and the Arizona Wildcats at Thompson-Boling Arena in Knoxville, Tenn., on Wednesday, Dec. 22, 2021.Kns Vols Arizona Hoops Bp /
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INDIANAPOLIS, INDIANA – MARCH 10: E.J. Liddell #32 of the Ohio State Buckeyes dribbles the ball against Jalen Pickett #22 of the Penn State Nittany Lions during the first half of a Men’s Big Ten Tournament second-round game at Gainbridge Fieldhouse on March 10, 2022, in Indianapolis, Indiana. (Photo by Aaron J. Thornton/Getty Images)
INDIANAPOLIS, INDIANA – MARCH 10: E.J. Liddell #32 of the Ohio State Buckeyes dribbles the ball against Jalen Pickett #22 of the Penn State Nittany Lions during the first half of a Men’s Big Ten Tournament second-round game at Gainbridge Fieldhouse on March 10, 2022, in Indianapolis, Indiana. (Photo by Aaron J. Thornton/Getty Images) /

March Madness officially kicks off with the start of the First Four Tuesday night but these 10 potential games would be highlights of the NCAA Tournament.

The NCAA Tournament is one of the most exciting events in sports since there are seemingly endless possibilities for how the 68-team bracket could play out. The only guarantees are the first-round matchups but playing out the results in specific ways could lead to very exciting contests as we advance deeper into March Madness.

After spending a lot of time analyzing the brackets, there are 10 matchups that stand out as being some of the most attractive games the NCAA Tournament could offer. We’ll start off in the Round of 64 and work our way deeper into the madness as we work our way through the month of March.

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Top potential March Madness games

10. South Region First Round – No. 7 Ohio State vs. No. 10 Loyola-Chicago

The only Round of 64 game to make the cut here is the first game of the day on Friday with Ohio State taking on Loyola-Chicago. The Buckeyes spent a ton of time in the Top 25 this season and have a bona fide star in E.J. Liddell as they look to redeem themselves after getting upset in this round a year ago by 15-seed Oral Roberts.

That task won’t be easy against the Ramblers, who made the NCAA Tournament despite Porter Moser’s departure for Oklahoma and Cameron Krutwig’s graduation. Lucas Williamson is the leader of a battle-tested group that has all the experience necessary to create a thrilling showdown at the start of Day 2.

9. East Region Round of 32 – No. 2 Kentucky vs. No. 7 Murray State

John Calipari usually finds a reason to complain about his draw in March Madness and he has a valid grievance here. Kentucky is a loaded squad capable of winning the national championship but they might draw the most dangerous No. 7 seed in the entire field, Murray State, in the Round of 32.

The Racers went 30-2 in the regular season and average nearly 80 points a game, setting the stage for a potential shootout in Indianapolis on Saturday. Forward K.J. Williams can also be a matchup problem, averaging 18.6 points and 8.6 rebounds per game, as Murray State will be highly motivated to knock off their in-state rivals.